Brand new endpoints Os, AFS, and independence out of amputation was in fact analysed having fun with multivariable time-oriented Cox regression patterns for the the full design (all the customers) with sex-correspondence conditions for each and every risk basis. This new activities having independence of amputation experienced dying because a contending risk weighed against new AFS models, including passing in the endpoint. For this function, i utilized Okay and you will Gray’s approach to guess sub-distributional risk ratios (HRs) about AFS design.
The models included risk profiles of patients at baseline and additionally time-dependent occurrence of comorbidities or procedures in the follow-up period. Thus, we evaluated the interaction of sex with all variables in the Cox regression models. Two-sided P-values for the test of interaction of the two models were jointly adjusted using the Benjamini–Hochberg procedure 34 to control the false discovery rate (FDR) with respect to the multiple testing problem.